Interactive projection

I’m in search of a software that can handle physical interaction and syphon it to a mapped projection.

Is openframeworks a solution for this??

A bit biased since I’m on this forum, but I would say: yes.
I’ve used ofxSyphon with succes and find it’s easy to implement.
Physical Interaction is a bit broad, but you can use ofxKinect for example.
Using sensors I would use a Raspberry Pi and ofxGPIO which is nicely documented.